Margaretta Colangelo Ventures is based in San Francisco. We are interested in entrepreneurs who have innovative ideas with worldwide growth potential. We are building an ecosystem of investors, entrepreneurs, and engineers in San Francisco, Los Angeles, New York, Boston, Austin, Washington D.C., Albuquerque, Barcelona, Valencia, London, Bangkok, Seoul, Bosnia, Kenya, Uganda, Ghana, Morocco, Ukraine and The Russian Federation. Our thirty years of experience developing software in Silicon Valley gives the founders we work with an important advantage.
Pitch us and send us your deck.
Quibim™ is a next generation imaging platform for clinical trials. Using AI enhanced digital imaging methodologies, Quibim detects early biological changes in organs and tissues induced by a given therapy and provides accurate quantitative information to doctors, clinicians and researchers. Quibim stands for QUantitative Imaging Biomarkers In Medicine.
PhenoMx™ is developing a digital physical exam to measure the major vital organs and tissues of the whole body using non-invasive MRI scanning. PhenoMx uses AI, particularly deep multi-layered neural networks, for image segmentation, co-registration, abnormality detection, and quantitative measurement.
Sutures™ is an interactive and life-like anatomy app designed by surgeons to help explain surgical procedures to patients, trainees and colleagues. The organs in the app are empowered by bio-mimicry principles and AI fundamentals so that they behave as actual organs do when reacting to external manipulation by surgeons.
Caffeine™ improves both network performance and security within iPhone applications. Caffeine embeds AI algorithms in its technology to predict when an app is about to use the network. This ahead-of-time knowledge allows Caffeine to optimize applications for future network conditions, moving data faster and more efficiently.
Sympler™ is a video messaging platform that converts content into conversation. We plug into client's web & social channels or existing apps & keyboards to enable fans to message with their favorite entertainment. Fans get to chat better and publishers get into the most important medium ever: messaging. Current clients include NBCUniversal & Universal Music Group.
Duma Works™ is the #1 online recruiting platform on the African continent. Duma fuses traditional human-centered recruiting with an interactive digital process to simplify how growing businesses hire top talent. Over 250 employers in Kenya, Uganda, Rwanda, Tanzania and throughout sub-saharan Africa use Duma Works to find top talent.
KHIRY™ is a luxury accessories brand that celebrates a global African aesthetic, and embodies strength, femininity, power, and romance. With a focus on minimalist silhouettes, maximalist embellishment and the reinterpretation of classic materials, KHIRY is redefining luxury. KHIRY has been recognized by Elle Magazine, Teen Vogue, Harper's Bazaar China, Wall Street Journal and Paper Magazine.
Reveal Bot™ is the first AI powered chat bot for advertising. Reveal manages your FaceBook and Instagram ad campaigns in Slack, alerts you to changes in CTR and CPC, and provides insights on how to improve inefficiencies. Reveal is currently available for FaceBook, Instagram and AdWords. Reveal for Twitter and Bing coming soon.
It takes 15 years for a cutting edge cancer treatment to be prescribed to you by your doctor. Mendel makes tomorrow's treatments available today by matching patients with clinical trials. Mendel's AI based proprietary trial matching system continuously updates any time a new treatment is open for clinical trials, finding breakthrough cancer treatments for you.
Sibly™ leverages human coaches, existing science, and AI to build the most accessible effective mental health professional in everyone's pocket. By applying tools such as reflective listening, motivational interviewing, cognitive behavioral skills, and other empirically-based tools, Sibly provides affordable, accessible, effective 24/7 counseling for everyone.
Gluru™ is an advanced productivity boosting app that uses artificial intelligence to streamline personal and professional workflows. The AI proactively retrieves information that is relevant to you from your email, identifies what you need to do, suggest actions you should take, and automates execution where necessary.
Kent '83, Sweet Briar '87
Managing Director, Margaretta Colangelo Ventures
President, U1 Technologies
In technology companies, thinking is the primary activity and the core process used to create value. One of the challenges when thinking about technology is keeping up with constant innovation and envisioning what will evolve next. To stay abreast of emerging technologies, we are building an ecosystem of entrepreneurs, engineers, scientists and investors who have innovative ideas. We are interested in artificial intelligence, machine learning, rejuvenation technology, life extension technology, biotechnology and precision medicine. Like a natural ecosystem, our ecosystem consists of interlinked resources that complement each other. As our community expands, the value of the ecosystem increases exponentially. These are some of the entrepreneurs, engineers and investors in our ecosystem with whom we collaborate regularly.
Kent '90, Conn College '94, Vanderbilt '04
Managing Director, Reva Capital Markets
Margaretta in a word is awesome. I have been fortunate to know her for a number of years and work with her on startups and non-profits. We serve on four startup advisory boards together and I hear nothing but high praise for her work effort and strong ethics. Margaretta is intelligent and creative. She works hard and smart. She thinks long-term and has an innate ability to execute on near-term projects which will lead to future success. She's a constant learner and reader which leads her to explore and find connections which are pertinent but were not previously thought of by others. When she works on a project, she focuses on it but also allows her mind to think through other permutations about how it could be done. Margaretta doesn't seek the spotlight. She works well with other people and she isn't looking for the limelight.
Colorado College '03
Managing Director, Autochrome Ventures
Margaretta's tireless work ethic and extraordinary insight are only exceeded by her kindness and generosity. As an emerging fund manager, she's been absolutely essential to building my network and enabling a successful transition from operator to investor. Any founder would be privileged to have access to her counsel, and any investor can trust that her contribution to a company's success will go far beyond simply writing a check.
Conn College '01
Partner, KEC Ventures
Margaretta is the sort of person I'd want beside me when my back is against the wall. She's also great fun to talk to about startups because of the depth of her experience in the technology sector.
Executive Director, DeliverFund
Margaretta is a force multiplier who is willing to leverage her vast network to propel you forward. Her advice is timely and relevant, but it is her genuine heart to change the world that makes her stand out from the crowd. Margaretta is the perfect combination of investor, advisor, social change agent, and friend.
Carnegie Mellon '12
Founder & CEO, Marinus Analytics
San Francisco and Pittsburgh
Margaretta is a champion for innovators and a pioneer in the tech startup sector. Her passion is infectious and her advice is golden. I have the honor of collaborating with her to investigate and push the potential of artificial intelligence to fight human trafficking online.
CUNY Hunter College '87
Big Data Expert, Hortonworks
Margaretta is one of the most intelligent people I have ever met, and her ethics are sterling. Margaretta and I met in 1997 when I was CEO of Advanced Web Technologies in New York City and Margaretta managed strategic partnerships at a partner software company in Silicon Valley. I was part of the team that recruited her in 2003 to be Director of Sales and Marketing at our company on Wall Street in New York. Margaretta was the single most successful sales director in our company history. Her tireless and laser focused efforts and professionalism brought us tremendous business and amazing new clients and partners. She single handedly brought in big accounts including: Barclay's Global, Standard and Poor's, NCR, Teradata, MITRE, Countrywide Financial, Enterprise Rent-a-Car, JP Morgan, Portland Gas & Electric Company, Pennsylvania State University, JBoss and Red Hat. Our company flourished under her sales leadership. I wholeheartedly recommend collaborating with Margaretta. She's not just a star, she's more like a quasar.
Co-founder, Caffeine Software
Thiel Fellow, Thiel Foundation
Margaretta is engaging, thoughtful, and fun! Willing to provide help and feedback regularly, she has been an asset to the building of our organization. If you have the opportunity to meet with her, take it.
Sanjeev Thohan, PhD
Towson '84, UAZ '90, UMD '98
Research Fellow Toxicology, Novartis
Margaretta is an inspirational collaborator and perseverant inquisitor. Our discussions range from the mainstream to the fringe and back again - ranging from quantum physics and the holistic approach for therapeutics to quantum medicine that underlies our basic understanding of systems biology (toxicology by sequelae) that will evolve to precision medicine. Margaretta is a rarity in today's world as most of us are trained to drill down into our disciplines to observe a singularity. I am grateful to know a like-minded contextual thinker and to be part of her ecosystem.
New York City
I was fortunate to meet Margaretta. She has become a mentor and much more. She is on the advisory board of my startup PhenoMx and has been extremely helpful introducing us to investors and helping us grow our business. Her insight and guidance have enabled many of my successes as a professional and will continue to in the future.
JMU '86, Pace '89
Founder & Managing Partner, Shift Group
Margaretta is an entrepreneur’s entrepreneur. She knows first hand the trials and tribulations of launching a business in today’s environment. She has become my ‘go-to’ confidant and mentor. Margaretta has been exceedingly helpful with her ideas and feedback with helping us launch Shift Group. Her energy, passion for entrepreneurship and unflagging get-it-done approach is exactly what every startup needs. If you have the opportunity to work with Margaretta, consider yourself incredibly fortunate. I can't imagine not working with her on my team!
Marketing Associate, Red Sift
Margaretta is a fantastic person to know. She has first hand experience working with startups to help them grow and she has certainly helped us a great deal. She has helped us get some great exposure for our growing startup and she is also helping us launch on Product Hunt. With all she does I am still trying to figure out the mystery of how she finds the time to do it all.
Choate '12, Hobart '17
Founder, Deals en Route
Margaretta is the kind of person you’d want in your corner. She is very high energy and knowledgeable about everything tech-related. She offers introductions to key people to help every one of us reach our potential. She's a great advisor who is helping entrepreneurs tackle the most salient issues affecting the world today.
Matteo Tadjo Kotch
King's College '16
Product Marketing, Gluru
Margaretta is one of the most genuine people that I've met to date. The impression that she's had on me and on the business that I work for far exceeds all of my expectations. Her sheer generosity and good-will inspires her to provide professional advice and suggestions. This all stems from her desire to see all the startups that she believes in succeed. This testimonial in itself will not be able to adequately convey just how amazing she is, however, all one needs to do is read the additional testimonials (above and below) to see just how important she is to all of us.
Kazan State '11, Rochester '12
New York, Kazan, Moscow
When we were introduced to Margaretta and had our first call with her, we were really inspired by the excitement and enthusiasm she radiated. She quickly got into the details of our business and helped with some great advice and connections right away. Her knowledge of new technology and markets, her interest in learning about new things (from AI to the Russian startup ecosystem) as well as her willingness to share her experience makes Margaretta a great advisor!
Exeter '13, Penn'17
Founder & CEO, KHIRY
When I was a student at Phillips Exeter Academy, I reached out to Margaretta for help securing an internship at fashion company Narciso Rodriguez. I loved to design, but I had no idea how to break into the fashion industry, especially while still in high school. Thanks to Margaretta's help, I was able to secure an internship at Narciso Rodriguez, which led to many amazing opportunities and really solidified my desire to work in the industry. Since then, I've even launched my own company, all stemming from the support I received from Margaretta. Margaretta is the Empress of all things Tech.
Boston and Nairobi
I am incredibly honored to be working with Margaretta. Margaretta believes in us and understands our vision for Yakutti. Her optimism, enthusiasm and her ideas are inspiring, as is her genuine warmth. You couldn’t find a more committed advisor.
Co-Founder, Duma Works
I've really enjoyed working with Margaretta as an advisor. She brings a very fresh perspective and energy to your ideas that you can't help but be inspired by. She connects people effortlessly and genuinely. She is also the guru I turn to for social media and content strategy advice. Margaretta is quick to respond and quicker to help!
Kevin K. Ross-Andino
Kent '83, Vanderbilt '89
President, éClat Law
Margaretta is a high-energy and driven individual, the perfect personality to lead a major organization or spearhead the startup of a sophisticated business venture. Her creativity and innovation are of the ilk necessary to transform the mundane into the successful, especially in the area of marketing one's business or business concepts. I highly recommend that you consider collaborating with her on any project for which you expect to achieve success.
St. Mark's '88, Conn College '91
Margaretta is a true star, the rare talent who simply gets it. Her instincts for business in general and emerging trends and technology in particular set her apart and make her invaluable as a partner and advisor. From an investment standpoint, she also goes beyond simply cutting a check and waiting for something to happen. If she invests in your company, she believes in it and will passionately work just as hard as you do to make it succeed. Margaretta, simply put, is one of the good ones. I highly, highly recommend collaborating with her!
University of Nairobi Law School '17
Margaretta has been, and continues to be, a great advisor to us at Yakutti. Her invaluable power of networking and mentoring has indeed been of great use to our startup as both an advisor and a mentor. She inspires teams by simply demonstrating the invaluable importance of being a visionary team player. We look forward to rising to greater heights at Yakutti with her and would definitely recommend her to any start up team looking to walk the distance and make a difference.
Founder & CEO, Golden
Margaretta is on point. She is very sharp and capable of distilling issues to their core very quickly. She can immediately put founders in touch with the best person to talk to get what they need. She is very efficient, very technical, and very entrepreneur-friendly. She is the sort of person who could help any entrepreneur at virtually any step of their business, and be a good partner and sounding board
Universidad Adolfo Ibáñez '07, '09
Cofounder and CMO, Suggestic
San Francisco and Mexico City
Margaretta provides great feedback and is a genius connector. She is passionate about helping us succeed. It has been a pleasure to work with her. I have no doubt that even greater things are still to come.
Javier González Zabaleta
Universidad Rey Juan Carlos
CEO & Co-Founder, Medimsight
London and Madrid
Margaretta and I share a common vision of building an ecosystem of doctors, researchers, entrepreneurs and investors around the world who collaborate to improve healthcare. Margaretta's experience and advice are valuable to me and to many other biotech entrepreneurs around the world. Margaretta has also helped my startup connect with other startups and create valuable partnerships. I look forward to continued collaboration.
Ioannis Tarnanas, PhD
Aristotle University of Thessaloniki
Senior Research Associate, ETH
Margaretta is a force multiplier who is multiplying our unfair competitive advantage. Margaretta and I believe that data and intelligence will be the ultimate unfair competitive advantage for the next 10 years. And, as the power of big data is harnessed for medical progress, we must engage the next generation of scientists — and the public — and inform and educate them in the art and science of what is possible.
Meg Moss Guegan
Sweet Briar '92, GMU '99
Director of Development Communications, Cato Institute
Margaretta is that extremely rare kindred spirit who has the ability to see invisible connections between networks of all kinds and realize incredible potential not previously imagined. Working with her always inspires me to think a few steps beyond what is possible. Her passion for life and positive energy are endlessly abundant - and completely contagious!
Manchester Metropolitan '99
We were introduced to Margarettta by a colleague from the NYC startup ecosystem and quickly saw that she was one of the few people who truly understands where things are going in the media and messaging spaces. Our conversations have been profound as well as genuinely entertaining!
Founder & CEO, Sandboxx
Margaretta and I connected via a shared passion for effective communication platforms. As we grow users, features and employees here at Sandboxx, having a community to help think about UX behavior and designed scaling is incredibly powerful. The folks in this ecosystem are here to make their technology platforms better every day for their community and to help others who want to go in the same direction. I look forward to continued collaboration with Margaretta and her ecosystem. Hats off to Margaretta for pulling us together.
We were introduced to Margarettta by a colleague from the NYC startup ecosystem and quickly saw that she was one of the few people who truly understands where things are going in the media and messaging spaces. Our conversations have been profound as well as genuinely entertaining!
Kent '98, NYU '02
Margaretta offers more than her vast expertise in Silicon Valley. As a trusted advisor, her infectious optimism cuts through the daily noise leaving behind only the best insights. If you have the good fortune of earning her faith and support, she will fight tirelessly to see you go all the way. We are lucky to have her in our corner.
Margaretta has been wonderful to work with. She has endless energy and passion for startups and technology, and is always willing to brainstorm new ideas. She’s creative, well-networked, and proactive about connecting people in her network who can help each other. She always over-delivers on her promises, and her feedback and advice is always spot-on. In short, she’s a great person and a tremendously valuable resource for entrepreneurs.
Mark Angus Meyer
Andover '13, UChicago '18
Founding Team, Getmii
Generous and exceptionally thoughtful with her advice, Margaretta serves as a brilliant mentor to the Getmii team. Her sophisticated network covers a vast array of key verticals, opening the door to a great breadth of talented individuals. Margaretta is especially diligent in her approach to delivering advice and keeping our team aware of real time events and opportunities that consistently inform and advance the position of Getmii on the road ahead.
Associate Technical Client Manager, AppNexus
Margaretta offers endless guidance from her repertoire of experiences. She's willing to go out of her way to listen to one's ideas and offer feedback to create the most effective means of execution. Her ability to connect individuals in the start-up sphere is very valuable. She's a great person to work with and her energy is contagious!
Deerfield, Conn College
Margaretta appreciates the power of networks and how to leverage the expertise of a team to advance a project within a global context. Her enthusiasm is contagious and her expertise is invaluable as an idea blossoms into reality.
Wake Forest '16
Software Engineer, MicroStrategy
Margaretta is an extremely helpful advisor. She has a very high level of positive energy and passion for advising technology startups. The advice she has given me has been indispensable. I'm very excited to continue to work with Margaretta in the future!
Margaretta's understanding of the fast-paced tech startup environment has proven invaluable to ZealMe. Margaretta is a highly energetic, driven and passionate person. Her presence would be an important advantage to any individual or team.
Loomis '13, Trinity '17
From the moment I began working with Margaretta, she wasincredibly helpful. Her passion, enthusiasm, and experience advising technology startups has been invaluable to our team. I highly recommend her to any team looking to collaborate with a high energy, hard-working, and extremely intelligent person!
Kent '86, NYU '90
Over the course of my career, I have met many people from the corporate sector, but none with the passion to assist others like Margaretta. As a leader and long-time mentor, I understand the importance of working with a good mentor and I am extremely grateful to have Margaretta as one. She is a great listener and has helped me tremendously. I appreciate the time that Margaretta has given to me as I grow my business.There's nothing like having a mentor who understands where you came from, and where you're going. I have learned so much from Margaretta, and she has helped me to sharpen my focus. She has my full endorsement and thanks.
Middlesex '12, Cornell '16
Margaretta is one of the most valuable and tireless people working to integrate networks and link like-minded individuals. As a sophomore in college, I reached out to Margaretta for advice during my internship search. I was interested in research and government, but wanted more information about specific positions. She not only connected me to other prep school alumni with relevant previous experience, but encouraged my informational interview requests and gave me her support. Margaretta believes in getting to know people, and I am grateful for her enthusiasm and help in exploring career paths.
Member of the Board, Central Japan Railway
Margaretta has tremendous energy and a love for life and people that she translates into effective results. She operates at full speed all the time and is as adept with people as she is with cutting edge technology. Margaretta moves organizations to reach their potential and has the experience and the network necessary to achieve organizational goals and manage a complex organization.
Phantom Cyber Corporation
Margaretta and I worked together at Open Horizon for a number of years. Open Horizon was a startup in its early stages and Margaretta played a key role in all aspects of the company. Not only was she enjoyable to work with, but her decision making and overall understanding of the entire company was invaluable to the team at Open Horizon. All early stage companies need someone like Margaretta to help keep the team organized, focused and moving in the right direction.
Maritime Domain Awareness, CSCI
Margaretta is the best combination of energy, intelligence and enthusiasm that I have ever had the pleasure to work with. She is as comfortable in fast paced and often high risk commercial application development cycles as she is patient and thorough in the rigorous and often laborious military software development cycles. She understands people, process and product. Whenever there is an opportunity to collaborate with Margaretta, I jump at it because I know she will keep morale high and never let me down.
St. Paul's '81, NYU '88, Columbia '98
I have known Margaretta for over 25 years. She is a true and thorough professional with tremendous strength of character, integrity and business sense. Margaretta has outstanding communication skills and leadership ability. She is a genius at leveraging technology and social media to create value. Most importantly, Margaretta's keen intellect and clear, logical thought processes make her a stand out in her field. I adore her!
Kent '10, Brown'14
Founder, Ugly Juice
Margaretta has helped me and many others to connect with active Kent School alumni. Thanks to Margaretta, I was able to start a career in my preferred field, establish meaningful connections with CEOs and founders, and receive valuable feedback on my resume. Margaretta is an extremely helpful and passionate person and I encourage people to collaborate with her.
Deerfield '15, UC Berkeley '19
Margaretta has been a valuable resource in my transition from school to the professional world. She offers a plethora of helpful advice and her expertise ranges across industries. Every college student who is serious about networking and creating opportunities for themselves should have a Margaretta on their side.
Yu Yen Jordan Lee
Kent '13, Lehigh '17
Margaretta is a very passionate, energetic and humorous person who brings positivity and professionalism to the table. I was lucky to have met her. Due to her easy going nature, we hit it off right away. She has provided me with her expertise and thoughts about the tech market and offered to connect me with professionals in the financial world. Her kind words are truly encouraging and have given me more motivation to work even harder. Margaretta is an extremely generous and helpful person, and I am very fortunate to be able to call her a friend!
Exeter '14, Washington University of St. Louis '18
Founder, The Brookings Initiative
Seoul and Irvine
Margaretta has been an instrumental sounding board. She brings unparalleled energy and rich insight to the table. I am extremely excited to continue working with her throughout my entrepreneurial endeavors.
Kent '06, Lafayette '10
Scholarship Fund Director, Chelsea Piers
I first met Margaretta when I contacted her to see if she would be willing to introduce me to someone who worked for an organization in which I was interested. Margaretta immediately responded to my request and followed up with me after to see how my job search had progressed. She truly impacted my job search and helped me build bridges in a city that was completely new to me. I would definitely recommend Margaretta as a selfless, thoughtful and proactive connector who works hard to help others.
Chung Giam Lim
Middlesex '13, NYU '17
Brunei and NYC
Margaretta is one of the most positive, humorous, and down-to-earth people that I have had the pleasure of knowing. She sets the standard for the concept of going the extra mile. Not only did Margaretta give me invaluable advice regarding the professional world, but she also offered to help build my own network with her own number of extensive contacts. She even helped me stay on course and remain optimistic when facing challenges ahead. Margaretta is, without a doubt, an inspiring individual, and someone that any ambitious person should aspire to be like. I am extremely lucky and grateful to be able to have the pleasure of knowing her.
Kent '13, USC '17
When I first met Margaretta I was shocked to learn how widespread her personal and professional network extends but my surprise quickly dissipated upon getting to know her. Her effortlessly upbeat attitude, coupled with her extensive experience in both recognizing and acting upon groundbreaking trends makes her an invaluable asset to anyone’s network. Her selfless nature and genuine passion for giving back, adding value, and being a connector epitomize everything I love about Silicon Valley. I feel lucky to have the opportunity to collaborate with her.
Margaretta Colangelo is a native San Franciscan with 25 years of experience working for software companies in Silicon Valley. She has joined six early stage startups since 1992. She is building an ecosystem of entrepreneurs, investors, engineers, researchers, and authors who have innovative ideas with worldwide growth potential. Margaretta is an early adopter of emerging technologies and is interested in AI, machine learning, computer vision, regenerative medicine, biotechnology, and precision medicine. She has over 10,000 followers on LinkedIn and is active on AngelList and ProductHunt. Margaretta works with startup founders in San Francisco, Los Angeles, New York, Boston, Chicago, Austin, Washington D.C., Albuquerque, Barcelona, Valencia, Paris, Munich, Berlin, Zurich, Mexico City, Bangkok, Seoul, Bosnia, Israel, Morocco, Egypt, Saudi Arabia, Kenya, Ghana, Uganda, Ukraine and The Russian Federation.